MEF2C抗体
Applications
| Tested Applications: |
ELISA, WB, IHC |
| Specificity Reaction: |
Human,Mouse,Rat; Other species are not tested.Please decide the specificity by homology |
| Positive WB detected in |
Mouse cerebellum tissue, mouse brain tissue, mouse heart tissue, rat brain tissue |
| Positive IHC detected in |
Human brain tissue, human heart tissue, human kidney tissue, human lung tissue, human ovary tissue, human placenta tissue, human skin tissue, human spleen tissue, human testis tissue |
| Recommended dilution |
WB : 1:200-1:2000
IHC : 1:20-1:200 |
MEF2C抗体Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
Prev1Next
mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 18290-1-AP(MEF2C antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human brain using 18290-1-AP(MEF2C antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human brain using 18290-1-AP(MEF2C antibody) at dilution of 1:50 (under 40x lens)
Product Information MEF2C抗体
| Source: |
Rabbit |
Purify: |
Antigen affinity purification |
| IsoType: |
IgG |
Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information
| Immunogen: |
Peptide |
Full Name: |
Myocyte enhancer factor 2C |
Caculated Molecular
Weight: |
51 kDa |
Observed Molecular
Weight: |
51 kDa |
| GenbankNo |
NM_002397 |
GeneID: |
4208 |
| Symbol |
MEF2C |
Synonyms |
MEF2C, myocyte enhancer factor 2C |
Background
|
MEF2C belongs to the MEF2 family. It is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. It is crucial for normal neuronal development, distribution, and electrical activity in the neocortex and is necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. This protein is required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. It may also be involved in neurogenesis and in the development of cortical architecture. The immunogen used is peptide from Beta domain of MEF2C. The antibody can recognize the transcript variant 1 and transcript variant 3 of MEF2C. MEF2C抗体
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