COMT MaxPab mouse polyclonal antibody (B01)
产品名称： COMT MaxPab mouse polyclonal antibody (B01)
英文名称： COMT MaxPab mouse polyclonal antibody (B01)
产品编号： H00001312-B01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a full-length human COMT protein.
- Immunogen:
- COMT (NP_009294.1, 1 a.a. ~ 221 a.a) full-length human protein.
- Sequence:
- MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- No additive
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- Note:
- For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
- MSDS:
Download
- Publication Reference
- 1.
- Disturbed expression of phases I and II estrogen-metabolizing enzymes in endometrial cancer: Lower levels of CYP1B1 and increased expression of S-COMT.
Hevir N, Sinkovec J, Rizner TL.Mol Cell Endocrinol. 2010 Sep 29. [Epub ahead of print]
- Applications
- Western Blot (Tissue lysate)
- COMT MaxPab polyclonal antibody. Western Blot analysis of COMT expression in human placenta.
- Protocol Download
- Western Blot (Transfected lysate)
- Western Blot analysis of COMT expression in transfected 293T cell line (H00001312-T01) by COMT MaxPab polyclonal antibody.
Lane 1: COMT transfected lysate(24.31 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Entrez GeneID:
- 1312
- GeneBank Accession#:
- NM_007310.1
- Protein Accession#:
- NP_009294.1
- Gene Name:
- COMT
- Gene Alias:
- -
- Gene Description:
- catechol-O-methyltransferase
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq
- Other Designations:
- -
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