RELA polyclonal antibody
产品名称: RELA polyclonal antibody
英文名称: RELA polyclonal antibody
产品编号: PAB0836
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against a synthetic peptide of RELA.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human RELA.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.2% gelatin, 0.1% sodium azide)
- Storage Instruction:
- Store at 4°C. Do not freeze.
- Recommend Usage:
- Western Blot (1:400-1:1000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Enhancement of NF-kappaB expression and activity upon differentiation of human embryonic stem cell line SNUhES3.
Kang HB, Kim YE, Kwon HJ, Sok DE, Lee Y.Stem Cells Dev. 2007 Aug;16(4):615-23.
- 2.
- Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage.
Fan Z, Soder S, Oehler S, Fundel K, Aigner T.Am J Pathol. 2007 Sep;171(3):938-46. Epub 2007 Jul 19.
- 3.
- Direct role of NF-kappaB activation in Toll-like receptor-triggered HLA-DRA expression.
Lee KW, Lee Y, Kim DS, Kwon HJ.Eur J Immunol. 2006 May;36(5):1254-66.
- Entrez GeneID:
- 5970
- Gene Name:
- RELA
- Gene Alias:
- MGC131774,NFKB3,p65
- Gene Description:
- v-rel reticuloendotheliosis viral oncogene homolog A (avian)
- Omim ID:
- 164014
- Gene Ontology:
- Hyperlink
- Gene Summary:
- NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM
- Other Designations:
- nuclear factor of kappa light polypeptide gene enhancer in B-cells 3,v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)),v-rel reticuloendotheliosis viral oncogene homolog
- Gene Pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Apoptosis
- B cell receptor signaling pathway
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Epithelial cell signaling in Helicobacter pylori infection
- MAPK signaling pathway
- Neurotrophin signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- T cell receptor signaling pathway
- Toll-like receptor signaling pathway
- Related Disease
- Arthritis, Rheumatoid
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Disease Progression
- Disease Susceptibility
- Edema
- Genetic Predisposition to Disease
- Hematologic Diseases
- HIV Infections
- Hodgkin Disease
- Liver Cirrhosis
- Lymphoproliferative Disorders
- Multiple Myeloma
- Occupational Diseases
- Testicular Neoplasms
- Waldenstrom Macroglobulinemia
- Werner syndrome