HSP90AB1 monoclonal antibody, clone MBH90B
产品名称： HSP90AB1 monoclonal antibody, clone MBH90B
英文名称： HSP90AB1 monoclonal antibody, clone MBH90B
产品编号： MAB6458
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against synthetic peptide of HSP90AB1.
- Immunogen:
- A synthetic peptide corresponding to amino acids at N-terminus of human HSP90AB1.
- Sequence:
- EEVHHGEEEVEC
- Host:
- Mouse
- Reactivity:
- Bovine, Human, Mouse
- Specificity:
- This antibody recognizes the EEVHHG epitope within the N-terminal part of Hsp90b, an ubiquitously expressed protein with calculated MW of 83.3 KDa, however, migrating as a 90 KDa band under reducing SDS-PAGE conditions.
- Form:
- Liquid
- Concentration:
- 1 mg/mL
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Immunocytochemistry (1 mg/mL)
Western Blot (1 mg/mL)
Immunoprecipitation (1 mg/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The Hsp90 molecular chaperone: an open and shut case for treatment.
Pearl LH, Prodromou C, Workman P.Biochem J. 2008 Mar 15;410(3):439-53.
- 2.
- Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol.
Millson SH, Truman AW, Racz A, Hu B, Panaretou B, Nuttall J, Mollapour M, Soti C, Piper PW.FEBS J. 2007 Sep;274(17):4453-63. Epub 2007 Aug 6.
- 3.
- Blind cavefish and heat shock protein chaperones: a novel role for hsp90alpha in lens apoptosis.
Hooven TA, Yamamoto Y, Jeffery WR.Int J Dev Biol. 2004;48(8-9):731-8.
- Entrez GeneID:
- 3326
- Gene Name:
- HSP90AB1
- Gene Alias:
- D6S182,FLJ26984,HSP90-BETA,HSP90B,HSPC2,HSPCB
- Gene Description:
- heat shock protein 90kDa alpha (cytosolic), class B member 1
- Omim ID:
- 140572
- Gene Ontology:
- Hyperlink
- Gene Summary:
- HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM
- Other Designations:
- OTTHUMP00000016517,OTTHUMP00000016518,OTTHUMP00000016519,OTTHUMP00000039869,heat shock 90kD protein 1, beta,heat shock 90kDa protein 1, beta,heat shock protein beta
- Interactome
